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Nakagawa Francesca Nakagawa
Graduate Student

Department of Pharmacology
Center for Developmental Genetics, CMM room 348
Stony Brook University
Stony Brook, NY 11794-5130
(ph) 631-632-8438 (f) 631-632-1692

Francesca's Research Projects

The Role of TRAF4 in Mesoderm Formation

The TGF-β superfamily of signaling factors are required for proper development of the mesoderm, which forms the notochord, somites, heart, kidney, bones and blood. Within the TGF-β superfamily, Nodals play a role in initiating mesoderm formation and BMPs are involved in mesoderm patterning. Recently, the Thomsen lab used frog embryos to show that TRAF4 is a positive regulator of TGF-β signaling in vertebrate development. TRAF4 shares considerable structural homology with TRAFs 1,2,3,5 and 6, however, it does not share their functions in immunity, cell survival or apoptosis and its molecular functions are still not well understood. My project will investigate the role of TRAF4 in mesoderm development and its molecular function in TGF-β signaling.

Francesca's Education

Bachelor of Science
: Pharmacology
University of California, Santa Barbara

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